Module 2: Basic Pharmacology of Controlled Drugs and Substances
Cannabinoids – Pharmacokinetics
Pharmacokinetics of cannabinoids are impacted by the variety of formulations of the substances and routes of administration; including inhaled (smoked or vaporized), ingested (food or tea), or oral preparations (metered dose inhaler). Cannabinoids are metabolized in the liver and extra-hepatic tissue with elimination in urine, perspiration, feces, hair, and oral fluids. Exposure to these substances in terms of frequency, duration and amount, can influence the pharmacokinetics as well (Health Canada, 2013: Huestis, 2007).
- Health Canada. (2013). Information for Health Care Professionals: Cannabis (marihuana, marijuana) and the cannabinoids. Retrieved from http://www.hc-sc.gc.ca/dhp-mps/alt_formats/pdf/marihuana/med/infoprof-eng.pdf
- Huestis, M. A. (2007). Human cannabinoid pharmacokinetics. Chemistry and Biodiversity, 4(8), 1770–1804 (PDF). doi:10.1002/cbdv.200790152