Module 2: Basic Pharmacology of Controlled Drugs and Substances

Lesson 1

Benzodiazepines – Pharmacokinetics

Benzodiazepines are protein bound and lipid soluble. They are metabolized in the liver, which makes it important to carefully consider the use of these medications in the elderly and patients with liver disease. Their action may be prolonged in obese patients because of their protein binding as well. Onset, peak, and duration of action depend on whether the specific benzodiazepine is a short-, intermediate-, or long-acting agent – a factor which must be considered when prescribing.